- Take I-95 South.
- Take the I-395 North exit -- exit number 53 toward downtown.
- Merge onto I-395 North -- 0.40 miles.
- Take I-395 North toward Downtown/Inner Harbor.
- I-395 North becomes South Howard Street.
- Turn right onto West Pratt Street.
- World Trade Center will be on the right.
| - Take I-83 South.
- Take the I-695 West/I-83 exit toward Baltimore.
- Merge onto I-83 South.
- I-83 South becomes North President Street.
- Turn right onto East Lombard Street.
- Turn left onto South Street.
- Turn left onto East Pratt Street.
- World Trade Center will be on the right.
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